SynProt - The Portal to synaptic protein databases

Welcome to SynProt

The SynProt database is dedicated to proteins of detergent-resistant synaptic junctions fractions and primarily based on data obtained from twelve proteomics screens (see references). In addition, other well-known postsynaptic density proteins, or associated proteins, that have not been identified by proteomics analyses have been included. Currently the database contains more than 2500 non-redundant entries of rat, mouse and human proteins.

The following proteins are distinguished in SynProt: (i) proteins residing directly in the PSD (established PSD proteins such as PSD-95), (ii) proteins which are associated with the postsynaptic density by means of functional interaction with PSD proteins (such as Cortactin (Racz and Weinberg 2004)), (iii) proteins that are associated with either the presynaptic compartment, the synaptic extracellular matrix or astroglial endfeet contacting or tethered to the postsynaptic membrane, and (iv) co-fractionating proteins that behave like PSD proteins due to similar physico-chemical properties during the fractionation procedure.

To search for proteins and to contribute to the pool of detergent-resistant synaptic junction proteins in this database, please register (free for academic users).

The SynProt database is the first one of specific databases for different classes of brain proteins, which will be unified under the SynProt web portal for synaptic proteins.